Dysbiosis in Obese Wister Rats fed with Pakala (Phaseolus lunatus) and Iru (Parkia biglobosa)

1. Department of Medical Biochemistry, College of

*1Awoyinka, O.A., 1 Omodara, T.R.,2 Oladele, F.C., 1 Alese, M.O3 . Odesanmi, E.O4 Ajayi, D.D.3 Adeleye, G.S6 Olawumi, M.A2

Corresponding Author: olayinka.awoyinka@eksu.edu.ng

Recieved Date: December, 2020; Accepted Date: December, 2020; Published Date: December, 2020

ABSTRACT

Introduction: Obesity triggers a vast number of comorbidities associated with non- communicable diseases such as hypertension and diabetes. It is widely known that obesity is affected by numerous factors, such as diet and gut microbiota. These have been implicated in energy homeostasis and metabolic functions. Methodology: This study was designed to assess anti-obesity potential of underutilized wild beans- Phaseolus lunatus and Parkia biglobosa on wistar rats fed with high fat diets. Control and test groups of animals were fed with their respective diets for five weeks with close observation of Microbiota and histopathological study of the liver. Results: Obese rats fed with Phaseolus lunatus decreased in weights (p?0.05) effectively than obese rats fed with Parkia biglobosa. The gut microbiota was found to contain Proteus vulgaris, Escherichia coli, Bacillus cereus, and Enterobacter aerogenes while histopathological study shows liver of obese rats treated with fermented Parkia biglobosa had better restorative changes compared to obese rats treated with Phaseolus lunatus. Conclusion: This present study showed Phaseolus lunatus and Parkia biglobosa improved the health of obese animals by reducing the weights of the obese animals and also helps to have an insight to the level of effects of Phaseolus lunatus and Parkia biglobosa on liver organ in the treatment of obesity.